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Breast-Feeding Can Help Mom's Heart Decades Later
20-year study shows it cut risk factors linked to diabetes,
cardiovascular trouble

By Serena Gordon
HealthDay Reporter

THURSDAY, Dec. 3 (HealthDay News) -- Breast-feeding, even for just a
couple of months, can significantly lower a woman's risk of metabolic
syndrome -- a dangerous cluster of heart disease risk factors -- years
later, reports a new study appearing online Dec. 3 in the journal
Diabetes.

In women who didn't have pregnancy-related (gestational) diabetes,
breast-feeding between one and five months lowered a woman's risk of
developing metabolic syndrome by 39 percent, while breast-feeding for
the same duration lowered the risk of the syndrome by 44 percent in
women with gestational diabetes.

And, the longer a woman breast-fed, the better it was for her later
health. Breast-feeding for longer than nine months dropped the risk of
metabolic syndrome by 86 percent in women with gestational diabetes.
Women without gestational diabetes saw a 56 percent reduction in their
risk of metabolic syndrome, according to the study.

"Breast-feeding has favorable health benefits for women as well as for
children. Breast-feeding may help protect women from heart disease and
diabetes in the future," said the study's lead author, Erica
Gunderson, an epidemiologist and research scientist at the Kaiser
Permanente Division of Research in Oakland, Calif.

The benefits of breast-feeding for infants are well-documented and
include lower risk of ear infections, stomach problems, respiratory
illnesses, asthma, skin allergies, diabetes and sudden infant death
syndrome (SIDS). For women, breast-feeding appears to lower the risk
of type 2 diabetes, breast cancer, ovarian cancer and postpartum
depression, according to the U.S. Department of Health and Human
Services.

Metabolic syndrome arises when a group of cardiac risk factors occurs
in one person. Those risk factors include: abdominal obesity, high
blood pressure, low levels of HDL ("good") cholesterol, high levels of
LDL ("bad") cholesterol, high triglycerides, insulin resistance,
elevated markers of inflammation and a tendency for blood to clot,
according to the American Heart Association. People with metabolic
syndrome are significantly more likely to have or progress to heart
disease and type 2 diabetes than those without it.

For the current study, the researchers recruited almost 1,400 women
into a prospective, multi-center study designed to assess what factors
increase the risk of coronary artery disease. At the start of the
study in 1985, none of the women had been pregnant before, and none
had metabolic syndrome.

The women were examined at the start of the study, and again at 7, 10,
15 and 20 years after the start of the study.

While participating in the study, 704 of the women had babies. During
pregnancy, 84 women developed gestational diabetes. During the study
follow-up, 120 women developed metabolic syndrome.

Of those who developed metabolic syndrome, the average duration of
breast-feeding was 2.6 months, while the average time breast-feeding
for women who didn't develop metabolic syndrome was seven months,
according to the study.

"We found a very strong protective effect for lactation, and longer
duration is associated with a greater risk reduction," said Gunderson.

Although the researchers didn't study exactly how breast-feeding could
confer a benefit against heart disease so many years later, they
suspect that women who breast-feed are benefiting from higher good
cholesterol levels and less accumulation of belly fat. Both of these
are factors in metabolic syndrome. Additionally, Gunderson said that
breast-feeding helps with the metabolism of blood sugar, which may
lower their levels of insulin.

And, that's probably what's protecting these women, suggested Dr.
Jacob Warman, chief of endocrinology at the Brooklyn Hospital Center
in New York City. "I have a feeling that insulin is the culprit," he
said.

But, he noted that this study didn't measure levels of insulin, so
it's difficult to know for sure.

Still, he said, if women are concerned and would like to reduce their
risk even further, they should cut back on processed carbohydrates,
such as those found in sweets and in white breads, cereals and pastas.
"People with a high starch diet tend to have high insulin levels," he
explained.

Gunderson said that women who'd like to reduce their risk of metabolic
syndrome should follow health-eating guidelines, get regular exercise,
and if having a baby, consider breast-feeding. "Lactation is
potentially something that could have a benefit to your own health,"
she said.

More information

Learn more about the benefits of breast-feeding from the National
Women's Health Information Center.

SOURCES: Erica Gunderson, Ph.D., epidemiologist and research
scientist, Kaiser Permanente Division of Research, Oakland, Calif.;
Jacob Warman, M.D., chief of endocrinology, Brooklyn Hospital Center,
New York City; Dec. 3, 2009, Diabetes, online

Longer breastfeeding had a protective effect for metabolic syndrome

Mothers who breastfeed their children were less likely to develop metabolic syndrome, and the effect was more pronounced the longer breastfeeding continued, according to results of the CARDIA study.

Researchers said breastfeeding lowered the risk for metabolic syndrome by 39% to 56% for women with gestational diabetes and 44% to 86% for women without gestational diabetes.

CARDIA included 704 women aged 18 to 30 years. At baseline, these women had never given birth and were free of metabolic syndrome.

During 20 years of follow-up, researchers reported 120 new cases of metabolic syndrome after pregnancies. The overall incidence rate for metabolic syndrome was 22.1 per 1,000 person-years for women with gestational diabetes compared with 10.8 per 1,000 person-years for women without gestational diabetes.

When evaluating women by duration of lactation, the researchers determined that women who breastfed longer had lower incidence rates of metabolic syndrome. The protective effect was stronger among women who had gestational diabetes (relative hazard=0.14-0.56; P=.03) compared with those who did not (relative hazard=0.44-0.61; P=.03).

“The findings indicate that breastfeeding a child may have lasting favorable effects on a woman’s risk factors for later developing diabetes or heart disease,” Erica Gunderson, PhD, epidemiologist and research scientist in the division of research at Kaiser Permanente Northern California, said in a press release.

She added that the beneficial effect of breastfeeding did not appear to be associated with health behaviors such as differences in weight gain or physical activity. However, women who did not develop metabolic syndrome tended to have less abdominal fat and higher levels of HDL cholesterol.

Funded by the National Institutes of Health, the 20-year CARDIA study is the first to measure all components of metabolic syndrome both before pregnancy and after weaning in women of childbearing age, enabling researchers to examine breastfeeding in relation to new onset of metabolic syndrome, according to Gunderson.

Gunderson EP. Diabetes. 2009;doi:10.2337/db09-1197.

Home Births Can Be as Safe as Hospital Births in Low-Risk Women

NEW YORK (Reuters Health) Jul 28 - In terms of perinatal morbidity and mortality, a planned home birth is as safe as a planned hospital birth, provided that a well-trained midwife is available, a good transportation and referral system is in place, and the mother has a low risk of developing any complications, new research shows.

"Low-risk women should be encouraged to plan their birth at the place of their preference, provided the maternity care system is well equipped to underpin women's choice," Dr. A. de Jonge, from TNO Quality of Life, Leiden, the Netherlands, and co-researchers emphasize in the August issue of BJOG: An International Journal of Obstetrics and Gynaecology.

Data regarding the safety of home births in low-risk women are lacking, due in part to the fact that studies with very large sample sizes are needed to assess relatively rare adverse outcomes. Moreover, randomized trials comparing home and hospital births have not been done because women usually want to choose their place of birth, the authors explain.

The present study, an analysis of 529,688 low-risk planned births, was conducted in the Netherlands, the only country in the west with a large enough data set. The group included 321,307 women who wanted to give birth at home, 163,261 who planned to give birth in the hospital, and 45,120 with an unknown intended place of birth.

All of the outcomes studied occurred with comparable frequency in the planned home and hospital birth groups. These included intrapartum death (0.03% vs. 0.04%), intrapartum and neonatal death within 24 hours of birth (0.05% vs. 0.05%), intrapartum and neonatal death within 7 days (0.06% vs. 0.07%), and neonatal admission to an intensive care unit (0.17% vs. 0.20%).

"As far as we know, this is the largest study into the safety of home births," the authors note. The findings, they conclude, indicate that with proper services in place, home births are just as safe as hospital births for low-risk women.

BJOG 2009;116:1177-1184.

Reuters Health Information © 2009 

Outcomes of planned home birth with registered midwife versus planned hospital birth with midwife or physician

Patricia A. Janssen, PhD, Lee Saxell, MA, Lesley A. Page, PhD, Michael C. Klein, MD, Robert M. Liston, MD and Shoo K. Lee, MBBS PhD

From the School of Population and Public Health (Janssen), the Departments of Family Practice (Klein) and Obstetrics and Gynecology (Janssen, Liston) and the Division of Midwifery (Saxell), Faculty of Medicine, University of British Columbia, Vancouver, BC; the Child and Family Research Institute (Janssen, Klein, Liston), Vancouver, BC; the Nightingale School of Nursing and Midwifery (Page), King’s College, London, UK; the Department of Pediatrics (Lee); and the Integrated Centre for Care Advancement Through Research (Lee), University of Alberta, Edmonton, Alta.

Correspondence to: Dr. Patricia A. Janssen, School of Population and Public Health, University of British Columbia, 5804 Fairview Cres., Vancouver BC V6T 1Z3; fax 604 806-8006; pjanssen@interchange.ubc.ca

Background: Studies of planned home births attended by registered midwives have been limited by incomplete data, nonrepresentative sampling, inadequate statistical power and the inability to exclude unplanned home births. We compared the outcomes of planned home births attended by midwives with those of planned hospital births attended by midwives or physicians.

Methods: We included all planned home births attended by registered midwives from Jan. 1, 2000, to Dec. 31, 2004, in British Columbia, Canada (n = 2889), and all planned hospital births meeting the eligibility requirements for home birth that were attended by the same cohort of midwives (n = 4752). We also included a matched sample of physician-attended planned hospital births (n = 5331). The primary outcome measure was perinatal mortality; secondary outcomes were obstetric interventions and adverse maternal and neonatal outcomes.

Results: The rate of perinatal death per 1000 births was 0.35 (95% confidence interval [CI] 0.00–1.03) in the group of planned home births; the rate in the group of planned hospital births was 0.57 (95% CI 0.00–1.43) among women attended by a midwife and 0.64 (95% CI 0.00–1.56) among those attended by a physician. Women in the planned home-birth group were significantly less likely than those who planned a midwife-attended hospital birth to have obstetric interventions (e.g., electronic fetal monitoring, relative risk [RR] 0.32, 95% CI 0.29–0.36; assisted vaginal delivery, RR 0.41, 95% 0.33–0.52) or adverse maternal outcomes (e.g., third- or fourth-degree perineal tear, RR 0.41, 95% CI 0.28–0.59; postpartum hemorrhage, RR 0.62, 95% CI 0.49–0.77). The findings were similar in the comparison with physician-assisted hospital births. Newborns in the home-birth group were less likely than those in the midwife-attended hospital-birth group to require resuscitation at birth (RR 0.23, 95% CI 0.14–0.37) or oxygen therapy beyond 24 hours (RR 0.37, 95% CI 0.24–0.59). The findings were similar in the comparison with newborns in the physician-assisted hospital births; in addition, newborns in the home-birth group were less likely to have meconium aspiration (RR 0.45, 95% CI 0.21–0.93) and more likely to be admitted to hospital or readmitted if born in hospital (RR 1.39, 95% CI 1.09–1.85).

Interpretation: Planned home birth attended by a registered midwife was associated with very low and comparable rates of perinatal death and reduced rates of obstetric interventions and other adverse perinatal outcomes compared with planned hospital birth attended by a midwife or physician.

CMAJ (Canadian Medical Association Journal) September 15, 2009.